Fotoquímica y Fotobiología

Datos del Grupo

• Denominación: FQM-247 - Fotoquímica y Fotobiología

• Año de creación: 1995

• Responsable: Ángel Orte Gutiérrez

• Página web

• Twitter: @PPhotobiology

• e-mail: photochem@ugr.es

Intereses de la investigación

• Desarrollo de sondas fluorescentes para cuantificación intracelular de analitos de interés biomédico.

• Desarrollo de nuevas metodologías de diagnóstico del cáncer mediante nanosensores fluorescentes.

• Estudio de agregados amiloides a nivel de moléculas individuales.

Miembros del Grupo

Publicaciones

Para la lista completa visitar los perfiles de Google Scholar o Publons de los miembros del grupo. En la web del grupo también se puede encontrar una lista de publicaciones recientes.

2025

1. A. M. Diniz, C. I. C. Crucho, M. J. Ruedas-Rama, A. Orte, C. J. Dias, M. Outis, S. N. Pinto, M. A. F. Faustino, M. N. Berberan-Santos, J. Avó, TADF-Emitting Nanoparticles for Application as Probes in Time-Resolved Imaging and 1O2 Photosensitizers, Adv. Opt. Mater. 2025, 13, 2402063.
2. C. González-González, R. Lopez-Blanco, J. A. González-Vera, S. D’Ingiullo, D. Bouzada, M. Melle-Franco, A. Orte, M. E. Vázquez, Non-aromatic fluorescence from single \alpha-helical peptides, Cell Rep. Phys. Sci. 2025, 6, 102631.
3. S. Sultan, L. Crovetto, R. Rios, Recent advances in the development of enantiopure BODIPYs and some related enantiomeric compounds, Chem. Commun. 2025, 61, 1989-2010.

2024

1. Y. Appiarius, S. Míguez-Lago, P. Puylaert, N. Wolf, S. Kumar, M. Molkenthin, D. Miguel, T. Neudecker, M. Juríček, A. G. Campaña, A. Staubitz, Boosting quantum yields and circularly polarized luminescence of penta- and hexahelicenes by doping with two BN-groups, Chem. Sci. 2024, 15, 466-476.
2.  M. A. Hossain, S. Illescas-Lopez, M. W. Rahman, M. C. Mañas Torres, R. Contreras-Montoya, S. Firouzeh, J. A. Gavira, L. Álvarez de Cienfuegos, S. Pramanik, Efficient Transfer of Chirality in Complex Hybrid Materials and Impact on Chirality-induced Spin Selectivity, Chemistry of Materials 2024, 36, 11449-11461.
3. Y. Karibjanova, I. Rodriguez-Ruiz, A. Orte, J. A. Gavira, P. Roblin, S. Teychené, Fluorescence lifetime measurements of molecular rotors for protein solubility prediction through non-specific interactions characterization, J. Mol. Liq. 2024, 415, 126350.
4. A. Navarro, A. Ruiz-Arias, F. Fueyo-González, C. Izquierdo-García, T. Peña-Ruiz, M. Gutiérrez-Rodríguez, R. Herranz, J. M. Cuerva, J. A. González-Vera, A. Orte, Multiple pathways for lanthanide sensitization in self-assembled aqueous complexes, Spectrochim. Acta A 2024, 323, 124926.
5. M. Padial-Jaudenes, M. Tabraue-Chávez, S. Detassis, M. J. Ruedas-Rama, M. C. Gonzalez-Garcia, M. A. Fara, F. J. López-Delgado, J. A. González-Vera, J. J. Guardia-Monteagudo, J. J. Diaz-Mochon, E. Garcia-Fernandez, S. Pernagallo, A. Orte, Multiplexed MicroRNA biomarker detection by bridging lifetime filtering imaging and dynamic chemical labeling, Sens. Actuat. B-Chem. 2024, 417, 136136.
6. A. Ruiz-Arias, F. Fueyo-González, C. Izquierdo-García, A. Navarro, M. Gutiérrez-Rodríguez, R. Herranz, C. Burgio, A. Reinoso, J. M. Cuerva, A. Orte, J. A. González-Vera, Exchangeable Self-Assembled Lanthanide Antennas for PLIM Microscopy, Angew. Chem. Int. Ed. 2024, 63, e202314595.
7. R. Salto, M. D. Giron, J. M. Paredes, Genetically encoded red fluorescent pH ratiometric sensor: Application to measuring pH gradient abnormalities in cystic fibrosis cells, Sens. Actuat. B-Chem. 2024, 410, 135673.
8. R. G. Uceda, A. Gijón, S. Míguez-Lago, C. M. Cruz, V. Blanco, F. Fernández-Álvarez, L. Álvarez de Cienfuegos, M. Molina-Solana, J. Gómez-Romero, D. Miguel, A. J. Mota, J. M. Cuerva, Can Deep Learning Search for Exceptional Chiroptical Properties? The Halogenated [6]Helicene Case, Angew. Chem. Int. Ed. 2024, 63, e202409998.

2023

1. R. Contreras-Montoya, J. P. Smith, S. C. Boothroyd, J. A. Aguilar, M. Mirzamani, M. A. Screen, D. S. Yufit, M. Robertson, L. He, S. Qian, H. Kumari, J. W. Steed, Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs, Chem. Sci. 2023, 14, 11389-11401.
2. F. Fueyo-González, G. Vilanova, M. Ningoo, N. Marjanovic, J. A. González-Vera, Á. Orte, M. Fribourg, Small-molecule TIP60 inhibitors enhance regulatory T-cell induction through TIP60-P300 acetylation crosstalk, iScience 2023, 26, 108491.
3. M. C. Gonzalez-Garcia, E. Garcia-Fernandez, J. L. Hueso, P. M. R. Paulo, A. Orte, Optical Binding-Driven Micropatterning and Photosculpting with Silver Nanorods, Small Methods 2023, 7, 2300076.
4. A. M. Ortuño, P. Reiné, L. Álvarez de Cienfuegos, I. R. Márquez, W. Dednam, E. B. Lombardi, J. J. Palacios, E. Leary, G. Longhi, V. Mujica, A. Millán, M. T. González, L. A. Zotti, D. Miguel, J. M. Cuerva, Chiral Single-Molecule Potentiometers Based on Stapled ortho- Oligo(phenylene)ethynylenes, Angew. Chem. Int. Ed. 2023, 62, e202218640.
5. M. Singh, A. Ingle, A. González, P. Mariathomas, R. Ramanathan, P. D. Taylor, A. J. Christofferson, M. J. S. Spencer, M. X. Low, T. Ahmed, S. Walia, S. Trasobares, R. Manzorro, J. J. Calvino, E. García-Fernández, A. Orte, J. M. Dominguez-Vera, V. Bansal, Repairing and Preventing Photooxidation of Few-Layer Black Phosphorus with β-Carotene, ACS Nano 2023, 17, 8083-8097.
6. J. Valverde-Pozo, J. M. Paredes, T. J. Widmann, C. Griñan-Lison, G. Ceccarelli, A. Gioiello, M. E. Garcia-Rubiño, J. A. Marchal, J. M. Alvarez-Pez, E. M. Talavera, Ratiometric Two-Photon Near-Infrared Probe to Detect DPP IV in Human Plasma, Living Cells, Human Tissues, and Whole Organisms Using Zebrafish, ACS Sensors 2023, 8, 1064-1075.

2022

1. J. Dietz, M. Oelkers, R. Hubrich, A. Pérez-Lara, R. Jahn, C. Steinem, A. Janshoff, Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin-1 -PI(4,5)P2 Interaction in Constrained Geometries, Nano Letters 2022, 22, 1449-1455.
2. F. Fueyo-González, L. Espinar-Barranco, R. Herranz, I. Alkorta, L. Crovetto, M. Fribourg, J. M. Paredes, A. Orte, J. A. González-Vera, Self-Assembled Lanthanide Antenna Glutathione Sensor for the Study of Immune Cells, ACS Sens. 2022, 7, 322-330.
3. S. I. S. Hendrikse, R. Contreras-Montoya, A. V. Ellis, P. Thordarson, J. W. Steed, Biofunctionality with a twist: the importance of molecular organisation, handedness and configuration in synthetic biomaterial design, Chemical Society Reviews 2022, 51, 28-42.
4. M. Kazem-Rostami, A. Orte, A. M. Ortuño, A. H. G. David, I. Roy, D. Miguel, A. Garci, C. M. Cruz, C. L. Stern, J. M. Cuerva, J. F. Stoddart, Helically Chiral Hybrid Cyclodextrin Metal–Organic Framework Exhibiting Circularly Polarized Luminescence, J. Am. Chem. Soc. 2022, 144, 9380-9389.
5. F. Rey-Tarrío, S. Guisán-Ceinos, J. M. Cuerva, D. Miguel, M. Ribagorda, E. Quiñoá, F. Freire, Photostability and Dynamic Helical Behavior in Chiral Poly(phenylacetylene)s with a Preferred Screw-Sense, Angew. Chem. Int. Ed. 2022, 61, e202207623.
6. Á. Ruiz-Arias, R. Jurado, F. Fueyo-González, R. Herranz, N. Gálvez, J. A. González-Vera, A. Orte, A FRET pair for quantitative and superresolution imaging of amyloid fibril formation, Sens. Actuat. B-Chem. 2022, 350, 130882.

2021

1. Wittig, S., et al., Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes. Nature Communications, (2021). 12(1): p. 858. https://doi.org/10.1038/s41467-021-21102-w.
2. Ripoll, C., et al., Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery. Pharmaceutics, (2021). 13(2): p. 254. https://www.mdpi.com/1999-4923/13/2/254.
3. Pérez-Lara, Á., et al., Characterization of PROPPIN–Phosphoinositide Binding by Stopped-Flow Fluorescence Spectroscopy, in Phosphoinositides: Methods and Protocols, R.J. Botelho, Editor. (2021), Springer US: New York, NY. p. 205-214. https://doi.org/10.1007/978-1-0716-1142-5_15.
4. Medel, M.A., et al., Octagon-embedded carbohelicene as chiral motif for CPL emission of saddle-helix nanographenes. Angew. Chem. Int. Ed, (2021). n/a(n/a). https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202015368.
5. Meazza, M., et al., Studying the reactivity of alkyl substituted BODIPYs: first enantioselective addition of BODIPY to MBH carbonates. Chem. Sci., (2021). http://dx.doi.org/10.1039/D0SC06574A.
6. Klionsky, D.J., et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, (2021): p. 1-382. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1797280.
7. Cercós, P., et al., Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs. Int. J. Mol. Sci., (2021). 22(3): p. 1419.

2020

1. Valverde-Pozo, J., et al., Detection by fluorescence microscopy of N-aminopeptidases in bacteria using an ICT sensor with multiphoton excitation: Usefulness for super-resolution microscopy. Sensor Actuat. B-Chem., (2020). 321: p. 128487. http://www.sciencedirect.com/science/article/pii/S0925400520308327.
2. Ruiz-González, N., et al., Molecular and supramolecular recognition patterns in ternary copper(II) or zinc(II) complexes with selected rigid-planar chelators and a synthetic adenine-nucleoside. J. Inorg. Biochem., (2020). 203: p. 110920. http://www.sciencedirect.com/science/article/pii/S0162013419304866.
3. Ruiz-Arias, Á., et al., Seeding and Growth of β-Amyloid Aggregates upon Interaction with Neuronal Cell Membranes. Int. J. Mol. Sci., (2020). 21(14): p. 5035. https://www.mdpi.com/1422-0067/21/14/5035.
4. Ripoll, C., et al., Mitochondrial pH Nanosensors for Metabolic Profiling of Breast Cancer Cell Lines. Int. J. Mol. Sci., (2020). 21(10): p. 3731. https://www.mdpi.com/1422-0067/21/10/3731.
5. Reine, P., et al., Simple Perylene Diimide Cyclohexane Derivative With Combined CPL and TPA Properties. Front. Chem., (2020). 8(306). https://www.frontiersin.org/article/10.3389/fchem.2020.00306.
6. Peyressatre, M., et al., Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation. Front. Chem., (2020). 8(691). https://www.frontiersin.org/article/10.3389/fchem.2020.00691.
7. Herrero-Foncubierta, P., et al., Simple and non-charged long-lived fluorescent intracellular organelle trackers. Dyes and Pigments, (2020). 183: p. 108649. http://www.sciencedirect.com/science/article/pii/S0143720820313462.
8. González-Vera, J.A., et al., Unusual spectroscopic and photophysical properties of solvatochromic BODIPY analogues of Prodan. Dyes and Pigments, (2020): p. 108510. http://www.sciencedirect.com/science/article/pii/S014372082030557X.
9. Gonzalez-Garcia, M.C., et al., Orthogonal cell polarity imaging by multiparametric fluorescence microscopy. Sens. Actuator B-Chem., (2020). 309: p. 127770. http://www.sciencedirect.com/science/article/pii/S0925400520301179.
10. Gonzalez-Garcia, M.C., et al., Building Accurate Intracellular Polarity Maps through Multiparametric Microscopy. Methods Protoc., (2020). 3(4): p. 78. https://www.mdpi.com/2409-9279/3/4/78.
11. Fueyo-González, F., et al., Fluorescence mechanism switching from ICT to PET by substituent chemical manipulation: Macrophage cytoplasm imaging probes. Dyes and Pigments, (2020). 175: p. 108172. http://www.sciencedirect.com/science/article/pii/S0143720819324921.
12. Fueyo-González, F., et al., Environment-Sensitive Probes for Illuminating Amyloid Aggregation In Vitro and in Zebrafish. ACS Sensors, (2020). 5: p. 2792-2799. https://doi.org/10.1021/acssensors.0c00587.
13. Fueyo-González, F., et al., Smart lanthanide antennas for sensing water. Chem. Commun., (2020). 56: p. 5484-5487. http://dx.doi.org/10.1039/D0CC01725F.
14. Fueyo-González, F., et al., Naphthalimide-based macrophage nucleus imaging probes. Eur. J. Med. Chem., (2020). 200: p. 112407. http://www.sciencedirect.com/science/article/pii/S0223523420303780.
15. Denofrio, M.P., et al., N-Methyl-β-carboline alkaloids: structure-dependent photosensitizing properties and localization in subcellular domains. Org. Biomol. Chem., (2020). 18(33): p. 6519-6530. http://dx.doi.org/10.1039/D0OB01122C.

2019

1. Zhang, Q., et al., Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport. J. Biol. Chem., (2019). 294: p. 4546-4571. http://www.jbc.org/content/early/2019/01/29/jbc.RA119.007421.abstract. Author copy
2. Ripoll, C., et al., A Quantum Dot-Based FLIM Glucose Nanosensor. Sensors, (2019). 19(22): p. 4992 (1-16). https://www.mdpi.com/1424-8220/19/22/4992.
3. Resa, S., et al., Optically active Ag(i): o-OPE helicates using a single homochiral sulfoxide as chiral inducer. Org. Biomol. Chem., (2019). 17(36): p. 8425-8434. http://dx.doi.org/10.1039/C9OB01573F.
4. Resa, S., et al., O–H and (CO)N–H bond weakening by coordination to Fe(II). Dalton Trans., (2019). http://dx.doi.org/10.1039/C8DT04689A.
5. Reine, P., et al., Chiral double stapled o-OPEs with intense circularly polarized luminescence. Chem. Commun., (2019). 55(72): p. 10685-10688. http://dx.doi.org/10.1039/C9CC04885E.
6. Puente-Muñoz, V., et al., New Thiol-Sensitive Dye Application for Measuring Oxidative Stress in Cell Cultures. Sci. Rep., (2019). 9(1): p. 1659. https://doi.org/10.1038/s41598-018-38132-y.
7. Paredes, J.M., et al., Design, synthesis and photophysical studies of improved xanthene dye to detect acetate. J. Photochem. Photobiol. A Chem., (2019). 371: p. 300-305. http://www.sciencedirect.com/science/article/pii/S1010603018314606.
8. Linares, F., et al., Multifunctional behavior of molecules comprising stacked cytosine–AgI–cytosine base pairs; towards conducting and photoluminescence silver-DNA nanowires. Chem. Sci., (2019). 10(4): p. 1126-1137. Edge Article. http://dx.doi.org/10.1039/C8SC04036B.
9. Jurado, R., et al., Apoferritin Protein Amyloid Fibrils with Tunable Chirality and Polymorphism. J. Am. Chem. Soc., (2019). 141(4): p. 1606-1613. https://doi.org/10.1021/jacs.8b11418.
10. Gonzalez-Garcia, M.C., et al., Coupled Excited-State Dynamics in N-Substituted 2-Methoxy-9-Acridones. Front. Chem., (2019). 7: p. 129 (1-13). https://www.frontiersin.org/article/10.3389/fchem.2019.00129.
11. García-Rubiño, M.E., et al., Probing the effect of N-alkylation on the molecular recognition abilities of the major groove N7-binding site of purine ligands. J. Inorg. Biochem., (2019). 200: p. 110801. http://www.sciencedirect.com/science/article/pii/S0162013419303496.
12. Garcia-Fernandez, E., et al., Time-Gated Luminescence Acquisition for Biochemical Sensing: miRNA Detection, in Fluorescence in Industry, B. Pedras, Editor. (2019), Springer International Publishing: Cham. p. 213-267. https://doi.org/10.1007/4243_2018_4.
13. Garcia-Fernandez, E., et al., miR-122 direct detection in human serum by time-gated fluorescence imaging. Chem. Commun., (2019). 55(99): p. 14958-14961. http://dx.doi.org/10.1039/C9CC08069D.
14. García Rubiño, M.E., et al., Phenformin as an Anticancer Agent: Challenges and Prospects. Int. J. Mol. Sci., (2019). 20(13): p. 3316. https://www.mdpi.com/1422-0067/20/13/3316.
15. Espinar-Barranco, L., et al., Synthesis, Photophysics, and Solvatochromic Studies of an Aggregated-Induced-Emission Luminogen Useful in Bioimaging. Sensors, (2019). 19(22): p. 4932. https://www.mdpi.com/1424-8220/19/22/4932.
16. Espinar-Barranco, L., et al., A solvatofluorochromic silicon-substituted xanthene dye useful in bioimaging. Dyes and Pigments, (2019). 168: p. 264-272.

2018

1. Ripoll, C., et al., Synthesis and Spectroscopy of Benzylamine-Substituted BODIPYs for Bioimaging. Eur. J. Org. Chem., (2018). 2018(20-21): p. 2561-2571. https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201800083. Author copy.
2. Resa, S., et al., Sulfoxide-Induced Homochiral Folding of ortho-Phenylene Ethynylenes (o-OPEs) by Silver(I) Templating: Structure and Chiroptical Properties. Chem. Eur. J., (2018). 24(11): p. 2653-2662. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201704897.
3. Reiné, P., et al., OFF/ON switching of circularly polarized luminescence by oxophilic interaction of homochiral sulfoxide-containing o-OPEs with metal cations. Chem. Commun., (2018). 54(99): p. 13985-13988. http://dx.doi.org/10.1039/C8CC08395A.
4. Reiné, P., et al., Exploring potentialities and limitations of stapled o-oligo(phenyleneethynylene)s (o-OPEs) as efficient circularly polarized luminescence emitters. Chirality, (2018). 30(1): p. 43-54. https://onlinelibrary.wiley.com/doi/abs/10.1002/chir.22774.
5. Reiné, P., et al., Pyrene-Containing ortho-Oligo(phenylene)ethynylene Foldamer as a Ratiometric Probe Based on Circularly Polarized Luminescence. J. Org. Chem., (2018). 83(8): p. 4455-4463. https://doi.org/10.1021/acs.joc.8b00162.
6. Pérez-Toro, I., et al., Copper(II) polyamine chelates as efficient receptors for acyclovir: syntheses, crystal structures and dft study. Polyhedron, (2018). 145: p. 218-226. http://www.sciencedirect.com/science/article/pii/S0277538718300780.
7. Leary, E., et al., The Role of Oligomeric Gold–Thiolate Units in Single-Molecule Junctions of Thiol-Anchored Molecules. J. Phys. Chem. C, (2018). 122(6): p. 3211-3218. https://doi.org/10.1021/acs.jpcc.7b11104.
8. Herrero-Foncubierta, P., et al., A Red-Emitting, Multidimensional Sensor for the Simultaneous Cellular Imaging of Biothiols and Phosphate Ions. Sensors, (2018). 18: p. 161. http://www.mdpi.com/1424-8220/18/1/161.
9. Delgado-Gonzalez, A., et al., Metallofluorescent Nanoparticles for Multimodal Applications. ACS Omega, (2018). 3(1): p. 144-153. http://dx.doi.org/10.1021/acsomega.7b01984.
10. Contreras-Montoya, R., et al., Iron nanoparticles-based supramolecular hydrogels to originate anisotropic hybrid materials with enhanced mechanical strength. Materials Chemistry Frontiers, (2018). 2(4): p. 686-699.

2017

1. Puente-Muñoz, V., et al., Efficient acetate sensor in biological media based on a selective Excited State Proton Transfer (ESPT) reaction. Sensor Actuat. B-Chem., (2017). 250: p. 623-628. http://www.sciencedirect.com/science/article/pii/S0925400517308080.
2. Paulo, P.M.R., et al., Tip-Specific Functionalization of Gold Nanorods for Plasmonic Biosensing: Effect of Linker Chain Length. Langmuir, (2017). 33(26): p. 6503-6510. https://www.ncbi.nlm.nih.gov/pubmed/28592111.
3. Ortega-Liebana, M.C., et al., Nitrogen-Induced Transformation of Vitamin C into Multifunctional Up-converting Carbon Nanodots in the Visible–NIR Range. Chem. Eur. J., (2017). 23(13): p. 3067-3073. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201604216.
4. Marquez, I.R., et al., Versatile synthesis and enlargement of functionalized distorted heptagon-containing nanographenes. Chem. Sci., (2017). 8(2): p. 1068-1074.
5. Gonzalez-Vera, J.A., et al., A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding. Sci. Rep., (2017). 7: p. 41293.
6. González-Vera, J.A., et al., Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity. Chem. Commun., (2017). 53(45): p. 6109-6112. http://dx.doi.org/10.1039/C6CC09948C.
7. Castello, F., et al., Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates. Sci. Rep., (2017). 7: p. 40065. http://dx.doi.org/10.1038/srep40065.

2016

1. Paredes, J.M., et al., Synchronous Bioimaging of Intracellular pH and Chloride Based on LSS Fluorescent Protein. ACS Chem. Biol., (2016). 11(6): p. 1652-1660. https://doi.org/10.1021/acschembio.6b00103.
2. Ortega-Liebana, M.C., et al., Nitrogen-Induced Transformation of Vitamin C into Multifunctional Up-converting Carbon Nanodots in the Visible–NIR Range. Chem. Eur. J., (2016). 23(13): p. 3067-3073. http://dx.doi.org/10.1002/chem.201604216.
3. Orte, A., et al., Effect of the substitution position (2, 3 or 8) on the spectroscopic and photophysical properties of BODIPY dyes with a phenyl, styryl or phenylethynyl group. RSC Adv., (2016). 6(105): p. 102899-102913.
4. Morcillo, S.P., et al., Stapled helical o-OPE foldamers as new circularly polarized luminescence emitters based on carbophilic interactions with Ag(I)-sensitivity. Chem. Sci., (2016). 7(9): p. 5663-5670.
5. Jurado, R., et al., Apoferritin fibers: a new template for 1D fluorescent hybrid nanostructures. Nanoscale, (2016). 8(18): p. 9648-9656. http://dx.doi.org/10.1039/C6NR01044J.
6. Gonzalez-Vera, J.A., et al., Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes. Chem. Commun., (2016). 52(62): p. 9652-9655.

2015

1. Tsytlonok, M., et al., Single-Molecule FRET Reveals Hidden Complexity in a Protein Energy Landscape. Structure, (2015). 23(1): p. 190-198.
2. Ruedas-Rama, M.J., et al., FLIM Strategies for Intracellular Sensing, in Advanced Photon Counting, P. Kapusta, M. Wahl, and R. Erdmann, Editors. (2015), Springer International Publishing. p. 191-223. http://dx.doi.org/10.1007/4243_2014_67.
3. Ripoll, C., et al., Intracellular Zn2+ detection with quantum dot-based FLIM nanosensors. Chem. Commun., (2015). 51(95): p. 16964-16967. http://dx.doi.org/10.1039/C5CC06676J.
4. Resa, S., et al., New Dual Fluorescent Probe for Simultaneous Biothiol and Phosphate Bioimaging. Chem. Eur. J., (2015). 21(42): p. 14772-14779. http://dx.doi.org/10.1002/chem.201502799.
5. Miguel, D., et al., Development of a New Dual Polarity and Viscosity Probe Based on the Foldamer Concept. Org. Lett., (2015). 17(11): p. 2844-2847.
6. Miguel, D., et al., Toward Multiple Conductance Pathways with Heterocycle-Based Oligo(phenyleneethynylene) Derivatives. J. Am. Chem. Soc., (2015). 137(43): p. 13818-13826. https://doi.org/10.1021/jacs.5b05637.
7. Jiao, L., et al., Unusual spectroscopic and photophysical properties of meso-tert-butylBODIPY in comparison to related alkylated BODIPY dyes. RSC Adv., (2015). 5(109): p. 89375-89388. http://dx.doi.org/10.1039/C5RA17419H.
8. Crovetto, L., et al., Photophysics of a Live-Cell-Marker, Red Silicon-Substituted Xanthene Dye. J. Phys. Chem. A, (2015). 119(44): p. 10854-10862. http://dx.doi.org/10.1021/acs.jpca.5b07898. Author copy
9. Castello, F., et al., The First Step of Amyloidogenic Aggregation. J. Phys. Chem. B, (2015). 119(26): p. 8260-8267. http://dx.doi.org/10.1021/acs.jpcb.5b01957.

2014

1. Ruedas-Rama, M.J., et al., Interaction of YOYO-3 with Different DNA Templates to Form H-Aggregates. J. Phys. Chem. B, (2014). 118(23): p. 6098-6106.
2. Ruedas-Rama, M.J., et al., pH sensitive quantum dot–anthraquinone nanoconjugates. Nanotechnology, (2014). 25: p. 195501.
3. Martin-Lasanta, A., et al., Novel ortho-OPE metallofoldamers: binding-induced folding promoted by nucleating Ag(i)-alkyne interactions. Chem. Sci., (2014). 5(12): p. 4582-4591. http://dx.doi.org/10.1039/C4SC01988A.
4. Martinez-Peragon, A., et al., Rational design of a new fluorescent ‘ON/OFF’ xanthene dye for phosphate detection in live cells. Org. Biomol. Chem., (2014). 12(33): p. 6432-6439. http://dx.doi.org/10.1039/C4OB00951G.
5. Martínez-Peragón, A., et al., Synthesis and Photophysics of a New Family of Fluorescent 9-alkyl Substituted Xanthenones. Chem. A Eur. J., (2014). 20: p. 447-455.
6. Lopez, S.G., et al., Fluorescence enhancement of a fluorescein derivative upon adsorption on cellulose. Photochemical & Photobiological Sciences, (2014). 13(9): p. 1311-1320.
7. Boens, N., et al., 8-HaloBODIPYs and Their 8-(C, N, O, S) Substituted Analogues: Solvent Dependent UV–Vis Spectroscopy, Variable Temperature NMR, Crystal Structure Determination, and Quantum Chemical Calculations. J. Phys. Chem. A, (2014). 118(9): p. 1576-1594. http://dx.doi.org/10.1021/jp412132y.

2013

1. Salinas-Castillo, A., et al., Carbon dots for copper detection with down and upconversion fluorescent properties as excitation sources. Chem. Commun., (2013). 49(11): p. 1103-1105. http://dx.doi.org/10.1039/C2CC36450F.
2. Ruedas-Rama, M.J., et al., Solving Single Biomolecules by Advanced FRET-Based Single-Molecule Fluorescence Techniques. Biophys. Rev. Lett., (2013). 08(03n04): p. 161-190. http://www.worldscientific.com/doi/abs/10.1142/S1793048013300041.
3. Paredes, J.M., et al., Real-Time Phosphate Sensing in Living Cells using Fluorescence Lifetime Imaging Microscopy (FLIM). J. Phys. Chem. B, (2013). 117(27): p. 8143-8149. http://dx.doi.org/10.1021/jp405041c.
4. Orte, A., et al., Fluorescence Lifetime Imaging Microscopy for the Detection of Intracellular pH with Quantum Dot Nanosensors. ACS Nano, (2013). 7(7): p. 6387-6395. http://dx.doi.org/10.1021/nn402581q.

2012

1. Ye, Y., et al., Ubiquitin chain conformation regulates recognition and activity of interacting proteins. Nature, (2012). 492(7428): p. 266-270. http://dx.doi.org/10.1038/nature11722.
2. Ruedas-Rama, M.J., et al., Fluorescent nanoparticles for intracellular sensing: A review. Anal. Chim. Acta, (2012). 751(0): p. 1-23. http://www.sciencedirect.com/science/article/pii/S0003267012013529.
3. Ruedas-Rama, M.J., et al., A chloride ion nanosensor for time-resolved fluorimetry and fluorescence lifetime imaging. Analyst, (2012). 137: p. 1500-1508. http://dx.doi.org/10.1039/C2AN15851E.
4. Paredes, J.M., et al., Effects of the anion salt nature on the rate constants of the aqueous proton exchange reactions. Phys. Chem. Chem. Phys., (2012). 14(16): p. 5795-5800. http://dx.doi.org/10.1039/C2CP24058K.
5. Paredes, J.M., et al., Early Amyloidogenic Oligomerization Studied through Fluorescence Lifetime Correlation Spectroscopy. Int. J. Mol. Sci., (2012). 13(8): p. 9400-9418. http://www.mdpi.com/1422-0067/13/8/9400.
6. Narayan, P., et al., The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide. Nat. Struct. Mol. Biol., (2012). 19(1): p. 79-83. http://dx.doi.org/10.1038/nsmb.2191.
7. Lopez, S.G., et al., Bulk and Single-Molecule Fluorescence Studies of the Saturation of the DNA Double Helix Using YOYO-3 Intercalator Dye. J. Phys. Chem. B, (2012). 116(38): p. 11561-11569. http://dx.doi.org/10.1021/jp303438d.
8. Gonzalez-Vera, J.A., Probing the kinome in real time with fluorescent peptides. Chem. Soc. Rev., (2012). 41(5): p. 1652-1664.
9. Cremades, N., et al., Direct Observation of the Interconversion of Normal and Toxic Forms of a-Synuclein. Cell, (2012). 149(5): p. 1048-1059. Link.
10. Boens, N., et al., Visible Absorption and Fluorescence Spectroscopy of Conformationally Constrained, Annulated BODIPY Dyes. J. Phys. Chem. A, (2012). 116(39): p. 9621-9631. http://dx.doi.org/10.1021/jp305551w.

Proyectos de investigación vigentes

• A novel platform for the direct profiling of circulating cell-free ribonucleic acids in biofluids (diaRNAgnosis)

  • Horizon 2020 MSCA-RISE 101007934

  • Coordinador: Salvatore Pernagallo (DestiNA Genomica). Investigador responsable en la UGR: Ángel Orte Gutiérrez.

  • Financiación total: 759,000€. Financiación para UGR: 87,400€

  • Duración: Enero 2021 - Diciembre 2024

• Encapsulación y liberación controlada de nutracéuticos basada en nuevos microgeles multisensibles y biocompatibles (GelSano)

  •  

    PID2023-149387OB-I0

• PARTNER GROUP - INSTITUTE MAX PLANCK OF BIOPHYSICS

  • Investigador principal: Ángel Pérez Lara

  • Financiación: 100,000€

  • Duración: Septiembre 2020 - Septiembre 2025

• NANOSCOPIO DE SÚPER-RESOLUCIÓN CON CAPACIDADES MULTIDIMENSIONALES PARA LA UNIDAD DE EXCELENCIA DE QUÍMICA APLICADA A BIOMEDICINA Y MEDIOAMBIENTE (UEQ)

  • EQC2018-004333-P . Plan Nacional I+D+i de ayudas a infraestructura.

  • Investigador responsable: Ángel Orte Gutiérrez

  • Financiación: 630,350€

  • Duración: Octubre 2018 - Diciembre 2020

• microRNA BIOMARKERS IN AN INNOVATIVE BIOPHOTONIC SENSOR KIT FOR HIGH-SPECIFIC DIAGNOSIS (miRNA-DisEASY)

  • Horizon 2020 MSCA-RISE 690866

  • Coordinadora: Cristina Ress (Optoelettronica Italia).

  • Investigador responsable en la : Ángel Orte Gutiérrez.

  • Financiación total: 455,500.00€

  • Financiación para : 27,000€

  • Duración: Diciembre 2015 - Diciembre 2019

Tesis Doctorales

Pueden consultarse en el enlace TESIS.

Colaboradores Habituales

• Juan M. Cuerva. UGR - Dept. Química Orgánica
  • Colaborador desde 2011
• Araceli González Campaña. UGR - Dept. Química Orgánica
  • Colaborador desde 2011
• M. Dolores Girón. UGR - Dept. Bioquímica y Biología Molecular II
  • Colaborador desde 2012
• Rafael Salto. UGR - Dept. Bioquímica y Biología Molecular II
  • Colaborador desde 2012
• Luis Álvarez de Cienfuegos. UGR - Dept. Química Orgánica
  • Colaborador desde 2015
• Juan J. Díaz Mochón. UGR - Dept. Química Farmacéutica y Orgánica
  • Colaborador desde 2014
• Noël Boens. U. Leuven (Bélgica) - Dept. Química
  • Colaborador desde 2003
• Natividad Gálvez. UGR - Dept. Química Inorgánica
  • Colaborador desde 2015
• Michela Denti. U. Trento (Italia) - CIBIO
  • Colaborador desde 2015
• Unidad de Excelencia en Química aplicada a Biomedicina y Medioambiente
  • Colaborador desde 2017