Fotoquímica y Fotobiología

Datos del Grupo

• Denominación: FQM-247 - Fotoquímica y Fotobiología

• Año de creación: 1995

• Responsable: Ángel Orte Gutiérrez

• Página web

• Twitter: @PPhotobiology

• e-mail: photochem@ugr.es

Intereses de la investigación

• Desarrollo de sondas fluorescentes para cuantificación intracelular de analitos de interés biomédico.

• Desarrollo de nuevas metodologías de diagnóstico del cáncer mediante nanosensores fluorescentes.

• Estudio de agregados amiloides a nivel de moléculas individuales.

Miembros del Grupo

Publicaciones

Para la lista completa visitar los perfiles de Google Scholar o Publons de los miembros del grupo. En la web del grupo también se puede encontrar una lista de publicaciones recientes.

2021

1. Wittig, S., et al., Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes. Nature Communications, (2021). 12(1): p. 858. https://doi.org/10.1038/s41467-021-21102-w.
2. Ripoll, C., et al., Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery. Pharmaceutics, (2021). 13(2): p. 254. https://www.mdpi.com/1999-4923/13/2/254.
3. Pérez-Lara, Á., et al., Characterization of PROPPIN–Phosphoinositide Binding by Stopped-Flow Fluorescence Spectroscopy, in Phosphoinositides: Methods and Protocols, R.J. Botelho, Editor. (2021), Springer US: New York, NY. p. 205-214. https://doi.org/10.1007/978-1-0716-1142-5_15.
4. Medel, M.A., et al., Octagon-embedded carbohelicene as chiral motif for CPL emission of saddle-helix nanographenes. Angew. Chem. Int. Ed, (2021). n/a(n/a). https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202015368.
5. Meazza, M., et al., Studying the reactivity of alkyl substituted BODIPYs: first enantioselective addition of BODIPY to MBH carbonates. Chem. Sci., (2021). http://dx.doi.org/10.1039/D0SC06574A.
6. Klionsky, D.J., et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, (2021): p. 1-382. https://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1797280.
7. Cercós, P., et al., Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs. Int. J. Mol. Sci., (2021). 22(3): p. 1419.

2020

1. Valverde-Pozo, J., et al., Detection by fluorescence microscopy of N-aminopeptidases in bacteria using an ICT sensor with multiphoton excitation: Usefulness for super-resolution microscopy. Sensor Actuat. B-Chem., (2020). 321: p. 128487. http://www.sciencedirect.com/science/article/pii/S0925400520308327.
2. Ruiz-González, N., et al., Molecular and supramolecular recognition patterns in ternary copper(II) or zinc(II) complexes with selected rigid-planar chelators and a synthetic adenine-nucleoside. J. Inorg. Biochem., (2020). 203: p. 110920. http://www.sciencedirect.com/science/article/pii/S0162013419304866.
3. Ruiz-Arias, Á., et al., Seeding and Growth of β-Amyloid Aggregates upon Interaction with Neuronal Cell Membranes. Int. J. Mol. Sci., (2020). 21(14): p. 5035. https://www.mdpi.com/1422-0067/21/14/5035.
4. Ripoll, C., et al., Mitochondrial pH Nanosensors for Metabolic Profiling of Breast Cancer Cell Lines. Int. J. Mol. Sci., (2020). 21(10): p. 3731. https://www.mdpi.com/1422-0067/21/10/3731.
5. Reine, P., et al., Simple Perylene Diimide Cyclohexane Derivative With Combined CPL and TPA Properties. Front. Chem., (2020). 8(306). https://www.frontiersin.org/article/10.3389/fchem.2020.00306.
6. Peyressatre, M., et al., Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation. Front. Chem., (2020). 8(691). https://www.frontiersin.org/article/10.3389/fchem.2020.00691.
7. Herrero-Foncubierta, P., et al., Simple and non-charged long-lived fluorescent intracellular organelle trackers. Dyes and Pigments, (2020). 183: p. 108649. http://www.sciencedirect.com/science/article/pii/S0143720820313462.
8. González-Vera, J.A., et al., Unusual spectroscopic and photophysical properties of solvatochromic BODIPY analogues of Prodan. Dyes and Pigments, (2020): p. 108510. http://www.sciencedirect.com/science/article/pii/S014372082030557X.
9. Gonzalez-Garcia, M.C., et al., Orthogonal cell polarity imaging by multiparametric fluorescence microscopy. Sens. Actuator B-Chem., (2020). 309: p. 127770. http://www.sciencedirect.com/science/article/pii/S0925400520301179.
10. Gonzalez-Garcia, M.C., et al., Building Accurate Intracellular Polarity Maps through Multiparametric Microscopy. Methods Protoc., (2020). 3(4): p. 78. https://www.mdpi.com/2409-9279/3/4/78.
11. Fueyo-González, F., et al., Fluorescence mechanism switching from ICT to PET by substituent chemical manipulation: Macrophage cytoplasm imaging probes. Dyes and Pigments, (2020). 175: p. 108172. http://www.sciencedirect.com/science/article/pii/S0143720819324921.
12. Fueyo-González, F., et al., Environment-Sensitive Probes for Illuminating Amyloid Aggregation In Vitro and in Zebrafish. ACS Sensors, (2020). 5: p. 2792-2799. https://doi.org/10.1021/acssensors.0c00587.
13. Fueyo-González, F., et al., Smart lanthanide antennas for sensing water. Chem. Commun., (2020). 56: p. 5484-5487. http://dx.doi.org/10.1039/D0CC01725F.
14. Fueyo-González, F., et al., Naphthalimide-based macrophage nucleus imaging probes. Eur. J. Med. Chem., (2020). 200: p. 112407. http://www.sciencedirect.com/science/article/pii/S0223523420303780.
15. Denofrio, M.P., et al., N-Methyl-β-carboline alkaloids: structure-dependent photosensitizing properties and localization in subcellular domains. Org. Biomol. Chem., (2020). 18(33): p. 6519-6530. http://dx.doi.org/10.1039/D0OB01122C.

2019

1. Zhang, Q., et al., Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport. J. Biol. Chem., (2019). 294: p. 4546-4571. http://www.jbc.org/content/early/2019/01/29/jbc.RA119.007421.abstract. Author copy
2. Ripoll, C., et al., A Quantum Dot-Based FLIM Glucose Nanosensor. Sensors, (2019). 19(22): p. 4992 (1-16). https://www.mdpi.com/1424-8220/19/22/4992.
3. Resa, S., et al., Optically active Ag(i): o-OPE helicates using a single homochiral sulfoxide as chiral inducer. Org. Biomol. Chem., (2019). 17(36): p. 8425-8434. http://dx.doi.org/10.1039/C9OB01573F.
4. Resa, S., et al., O–H and (CO)N–H bond weakening by coordination to Fe(II). Dalton Trans., (2019). http://dx.doi.org/10.1039/C8DT04689A.
5. Reine, P., et al., Chiral double stapled o-OPEs with intense circularly polarized luminescence. Chem. Commun., (2019). 55(72): p. 10685-10688. http://dx.doi.org/10.1039/C9CC04885E.
6. Puente-Muñoz, V., et al., New Thiol-Sensitive Dye Application for Measuring Oxidative Stress in Cell Cultures. Sci. Rep., (2019). 9(1): p. 1659. https://doi.org/10.1038/s41598-018-38132-y.
7. Paredes, J.M., et al., Design, synthesis and photophysical studies of improved xanthene dye to detect acetate. J. Photochem. Photobiol. A Chem., (2019). 371: p. 300-305. http://www.sciencedirect.com/science/article/pii/S1010603018314606.
8. Linares, F., et al., Multifunctional behavior of molecules comprising stacked cytosine–AgI–cytosine base pairs; towards conducting and photoluminescence silver-DNA nanowires. Chem. Sci., (2019). 10(4): p. 1126-1137. Edge Article. http://dx.doi.org/10.1039/C8SC04036B.
9. Jurado, R., et al., Apoferritin Protein Amyloid Fibrils with Tunable Chirality and Polymorphism. J. Am. Chem. Soc., (2019). 141(4): p. 1606-1613. https://doi.org/10.1021/jacs.8b11418.
10. Gonzalez-Garcia, M.C., et al., Coupled Excited-State Dynamics in N-Substituted 2-Methoxy-9-Acridones. Front. Chem., (2019). 7: p. 129 (1-13). https://www.frontiersin.org/article/10.3389/fchem.2019.00129.
11. García-Rubiño, M.E., et al., Probing the effect of N-alkylation on the molecular recognition abilities of the major groove N7-binding site of purine ligands. J. Inorg. Biochem., (2019). 200: p. 110801. http://www.sciencedirect.com/science/article/pii/S0162013419303496.
12. Garcia-Fernandez, E., et al., Time-Gated Luminescence Acquisition for Biochemical Sensing: miRNA Detection, in Fluorescence in Industry, B. Pedras, Editor. (2019), Springer International Publishing: Cham. p. 213-267. https://doi.org/10.1007/4243_2018_4.
13. Garcia-Fernandez, E., et al., miR-122 direct detection in human serum by time-gated fluorescence imaging. Chem. Commun., (2019). 55(99): p. 14958-14961. http://dx.doi.org/10.1039/C9CC08069D.
14. García Rubiño, M.E., et al., Phenformin as an Anticancer Agent: Challenges and Prospects. Int. J. Mol. Sci., (2019). 20(13): p. 3316. https://www.mdpi.com/1422-0067/20/13/3316.
15. Espinar-Barranco, L., et al., Synthesis, Photophysics, and Solvatochromic Studies of an Aggregated-Induced-Emission Luminogen Useful in Bioimaging. Sensors, (2019). 19(22): p. 4932. https://www.mdpi.com/1424-8220/19/22/4932.
16. Espinar-Barranco, L., et al., A solvatofluorochromic silicon-substituted xanthene dye useful in bioimaging. Dyes and Pigments, (2019). 168: p. 264-272.

2018

1. Ripoll, C., et al., Synthesis and Spectroscopy of Benzylamine-Substituted BODIPYs for Bioimaging. Eur. J. Org. Chem., (2018). 2018(20-21): p. 2561-2571. https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201800083. Author copy.
2. Resa, S., et al., Sulfoxide-Induced Homochiral Folding of ortho-Phenylene Ethynylenes (o-OPEs) by Silver(I) Templating: Structure and Chiroptical Properties. Chem. Eur. J., (2018). 24(11): p. 2653-2662. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201704897.
3. Reiné, P., et al., OFF/ON switching of circularly polarized luminescence by oxophilic interaction of homochiral sulfoxide-containing o-OPEs with metal cations. Chem. Commun., (2018). 54(99): p. 13985-13988. http://dx.doi.org/10.1039/C8CC08395A.
4. Reiné, P., et al., Exploring potentialities and limitations of stapled o-oligo(phenyleneethynylene)s (o-OPEs) as efficient circularly polarized luminescence emitters. Chirality, (2018). 30(1): p. 43-54. https://onlinelibrary.wiley.com/doi/abs/10.1002/chir.22774.
5. Reiné, P., et al., Pyrene-Containing ortho-Oligo(phenylene)ethynylene Foldamer as a Ratiometric Probe Based on Circularly Polarized Luminescence. J. Org. Chem., (2018). 83(8): p. 4455-4463. https://doi.org/10.1021/acs.joc.8b00162.
6. Pérez-Toro, I., et al., Copper(II) polyamine chelates as efficient receptors for acyclovir: syntheses, crystal structures and dft study. Polyhedron, (2018). 145: p. 218-226. http://www.sciencedirect.com/science/article/pii/S0277538718300780.
7. Leary, E., et al., The Role of Oligomeric Gold–Thiolate Units in Single-Molecule Junctions of Thiol-Anchored Molecules. J. Phys. Chem. C, (2018). 122(6): p. 3211-3218. https://doi.org/10.1021/acs.jpcc.7b11104.
8. Herrero-Foncubierta, P., et al., A Red-Emitting, Multidimensional Sensor for the Simultaneous Cellular Imaging of Biothiols and Phosphate Ions. Sensors, (2018). 18: p. 161. http://www.mdpi.com/1424-8220/18/1/161.
9. Delgado-Gonzalez, A., et al., Metallofluorescent Nanoparticles for Multimodal Applications. ACS Omega, (2018). 3(1): p. 144-153. http://dx.doi.org/10.1021/acsomega.7b01984.
10. Contreras-Montoya, R., et al., Iron nanoparticles-based supramolecular hydrogels to originate anisotropic hybrid materials with enhanced mechanical strength. Materials Chemistry Frontiers, (2018). 2(4): p. 686-699.

2017

1. Puente-Muñoz, V., et al., Efficient acetate sensor in biological media based on a selective Excited State Proton Transfer (ESPT) reaction. Sensor Actuat. B-Chem., (2017). 250: p. 623-628. http://www.sciencedirect.com/science/article/pii/S0925400517308080.
2. Paulo, P.M.R., et al., Tip-Specific Functionalization of Gold Nanorods for Plasmonic Biosensing: Effect of Linker Chain Length. Langmuir, (2017). 33(26): p. 6503-6510. https://www.ncbi.nlm.nih.gov/pubmed/28592111.
3. Ortega-Liebana, M.C., et al., Nitrogen-Induced Transformation of Vitamin C into Multifunctional Up-converting Carbon Nanodots in the Visible–NIR Range. Chem. Eur. J., (2017). 23(13): p. 3067-3073. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201604216.
4. Marquez, I.R., et al., Versatile synthesis and enlargement of functionalized distorted heptagon-containing nanographenes. Chem. Sci., (2017). 8(2): p. 1068-1074.
5. Gonzalez-Vera, J.A., et al., A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding. Sci. Rep., (2017). 7: p. 41293.
6. González-Vera, J.A., et al., Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity. Chem. Commun., (2017). 53(45): p. 6109-6112. http://dx.doi.org/10.1039/C6CC09948C.
7. Castello, F., et al., Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates. Sci. Rep., (2017). 7: p. 40065. http://dx.doi.org/10.1038/srep40065.

2016

1. Paredes, J.M., et al., Synchronous Bioimaging of Intracellular pH and Chloride Based on LSS Fluorescent Protein. ACS Chem. Biol., (2016). 11(6): p. 1652-1660. https://doi.org/10.1021/acschembio.6b00103.
2. Ortega-Liebana, M.C., et al., Nitrogen-Induced Transformation of Vitamin C into Multifunctional Up-converting Carbon Nanodots in the Visible–NIR Range. Chem. Eur. J., (2016). 23(13): p. 3067-3073. http://dx.doi.org/10.1002/chem.201604216.
3. Orte, A., et al., Effect of the substitution position (2, 3 or 8) on the spectroscopic and photophysical properties of BODIPY dyes with a phenyl, styryl or phenylethynyl group. RSC Adv., (2016). 6(105): p. 102899-102913.
4. Morcillo, S.P., et al., Stapled helical o-OPE foldamers as new circularly polarized luminescence emitters based on carbophilic interactions with Ag(I)-sensitivity. Chem. Sci., (2016). 7(9): p. 5663-5670.
5. Jurado, R., et al., Apoferritin fibers: a new template for 1D fluorescent hybrid nanostructures. Nanoscale, (2016). 8(18): p. 9648-9656. http://dx.doi.org/10.1039/C6NR01044J.
6. Gonzalez-Vera, J.A., et al., Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes. Chem. Commun., (2016). 52(62): p. 9652-9655.

2015

1. Tsytlonok, M., et al., Single-Molecule FRET Reveals Hidden Complexity in a Protein Energy Landscape. Structure, (2015). 23(1): p. 190-198.
2. Ruedas-Rama, M.J., et al., FLIM Strategies for Intracellular Sensing, in Advanced Photon Counting, P. Kapusta, M. Wahl, and R. Erdmann, Editors. (2015), Springer International Publishing. p. 191-223. http://dx.doi.org/10.1007/4243_2014_67.
3. Ripoll, C., et al., Intracellular Zn2+ detection with quantum dot-based FLIM nanosensors. Chem. Commun., (2015). 51(95): p. 16964-16967. http://dx.doi.org/10.1039/C5CC06676J.
4. Resa, S., et al., New Dual Fluorescent Probe for Simultaneous Biothiol and Phosphate Bioimaging. Chem. Eur. J., (2015). 21(42): p. 14772-14779. http://dx.doi.org/10.1002/chem.201502799.
5. Miguel, D., et al., Development of a New Dual Polarity and Viscosity Probe Based on the Foldamer Concept. Org. Lett., (2015). 17(11): p. 2844-2847.
6. Miguel, D., et al., Toward Multiple Conductance Pathways with Heterocycle-Based Oligo(phenyleneethynylene) Derivatives. J. Am. Chem. Soc., (2015). 137(43): p. 13818-13826. https://doi.org/10.1021/jacs.5b05637.
7. Jiao, L., et al., Unusual spectroscopic and photophysical properties of meso-tert-butylBODIPY in comparison to related alkylated BODIPY dyes. RSC Adv., (2015). 5(109): p. 89375-89388. http://dx.doi.org/10.1039/C5RA17419H.
8. Crovetto, L., et al., Photophysics of a Live-Cell-Marker, Red Silicon-Substituted Xanthene Dye. J. Phys. Chem. A, (2015). 119(44): p. 10854-10862. http://dx.doi.org/10.1021/acs.jpca.5b07898. Author copy
9. Castello, F., et al., The First Step of Amyloidogenic Aggregation. J. Phys. Chem. B, (2015). 119(26): p. 8260-8267. http://dx.doi.org/10.1021/acs.jpcb.5b01957.

2014

1. Ruedas-Rama, M.J., et al., Interaction of YOYO-3 with Different DNA Templates to Form H-Aggregates. J. Phys. Chem. B, (2014). 118(23): p. 6098-6106.
2. Ruedas-Rama, M.J., et al., pH sensitive quantum dot–anthraquinone nanoconjugates. Nanotechnology, (2014). 25: p. 195501.
3. Martin-Lasanta, A., et al., Novel ortho-OPE metallofoldamers: binding-induced folding promoted by nucleating Ag(i)-alkyne interactions. Chem. Sci., (2014). 5(12): p. 4582-4591. http://dx.doi.org/10.1039/C4SC01988A.
4. Martinez-Peragon, A., et al., Rational design of a new fluorescent ‘ON/OFF’ xanthene dye for phosphate detection in live cells. Org. Biomol. Chem., (2014). 12(33): p. 6432-6439. http://dx.doi.org/10.1039/C4OB00951G.
5. Martínez-Peragón, A., et al., Synthesis and Photophysics of a New Family of Fluorescent 9-alkyl Substituted Xanthenones. Chem. A Eur. J., (2014). 20: p. 447-455.
6. Lopez, S.G., et al., Fluorescence enhancement of a fluorescein derivative upon adsorption on cellulose. Photochemical & Photobiological Sciences, (2014). 13(9): p. 1311-1320.
7. Boens, N., et al., 8-HaloBODIPYs and Their 8-(C, N, O, S) Substituted Analogues: Solvent Dependent UV–Vis Spectroscopy, Variable Temperature NMR, Crystal Structure Determination, and Quantum Chemical Calculations. J. Phys. Chem. A, (2014). 118(9): p. 1576-1594. http://dx.doi.org/10.1021/jp412132y.

2013

1. Salinas-Castillo, A., et al., Carbon dots for copper detection with down and upconversion fluorescent properties as excitation sources. Chem. Commun., (2013). 49(11): p. 1103-1105. http://dx.doi.org/10.1039/C2CC36450F.
2. Ruedas-Rama, M.J., et al., Solving Single Biomolecules by Advanced FRET-Based Single-Molecule Fluorescence Techniques. Biophys. Rev. Lett., (2013). 08(03n04): p. 161-190. http://www.worldscientific.com/doi/abs/10.1142/S1793048013300041.
3. Paredes, J.M., et al., Real-Time Phosphate Sensing in Living Cells using Fluorescence Lifetime Imaging Microscopy (FLIM). J. Phys. Chem. B, (2013). 117(27): p. 8143-8149. http://dx.doi.org/10.1021/jp405041c.
4. Orte, A., et al., Fluorescence Lifetime Imaging Microscopy for the Detection of Intracellular pH with Quantum Dot Nanosensors. ACS Nano, (2013). 7(7): p. 6387-6395. http://dx.doi.org/10.1021/nn402581q.

2012

1. Ye, Y., et al., Ubiquitin chain conformation regulates recognition and activity of interacting proteins. Nature, (2012). 492(7428): p. 266-270. http://dx.doi.org/10.1038/nature11722.
2. Ruedas-Rama, M.J., et al., Fluorescent nanoparticles for intracellular sensing: A review. Anal. Chim. Acta, (2012). 751(0): p. 1-23. http://www.sciencedirect.com/science/article/pii/S0003267012013529.
3. Ruedas-Rama, M.J., et al., A chloride ion nanosensor for time-resolved fluorimetry and fluorescence lifetime imaging. Analyst, (2012). 137: p. 1500-1508. http://dx.doi.org/10.1039/C2AN15851E.
4. Paredes, J.M., et al., Effects of the anion salt nature on the rate constants of the aqueous proton exchange reactions. Phys. Chem. Chem. Phys., (2012). 14(16): p. 5795-5800. http://dx.doi.org/10.1039/C2CP24058K.
5. Paredes, J.M., et al., Early Amyloidogenic Oligomerization Studied through Fluorescence Lifetime Correlation Spectroscopy. Int. J. Mol. Sci., (2012). 13(8): p. 9400-9418. http://www.mdpi.com/1422-0067/13/8/9400.
6. Narayan, P., et al., The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide. Nat. Struct. Mol. Biol., (2012). 19(1): p. 79-83. http://dx.doi.org/10.1038/nsmb.2191.
7. Lopez, S.G., et al., Bulk and Single-Molecule Fluorescence Studies of the Saturation of the DNA Double Helix Using YOYO-3 Intercalator Dye. J. Phys. Chem. B, (2012). 116(38): p. 11561-11569. http://dx.doi.org/10.1021/jp303438d.
8. Gonzalez-Vera, J.A., Probing the kinome in real time with fluorescent peptides. Chem. Soc. Rev., (2012). 41(5): p. 1652-1664.
9. Cremades, N., et al., Direct Observation of the Interconversion of Normal and Toxic Forms of a-Synuclein. Cell, (2012). 149(5): p. 1048-1059. Link.
10. Boens, N., et al., Visible Absorption and Fluorescence Spectroscopy of Conformationally Constrained, Annulated BODIPY Dyes. J. Phys. Chem. A, (2012). 116(39): p. 9621-9631. http://dx.doi.org/10.1021/jp305551w.

Proyectos de investigación vigentes

• A novel platform for the direct profiling of circulating cell-free ribonucleic acids in biofluids (diaRNAgnosis)

  • Horizon 2020 MSCA-RISE 101007934

  • Coordinador: Salvatore Pernagallo (DestiNA Genomica). Investigador responsable en la UGR: Ángel Orte Gutiérrez.

  • Financiación total: 759,000€. Financiación para UGR: 87,400€

  • Duración: Enero 2021 - Diciembre 2024

• TG-DiAG: NUEVAS ESTRATEGIAS DE DIAGNÓSTICO BASADAS EN FLUORESCENCIA CON VENTANA TEMPORAL

  • CTQ2017-85658-R. Plan Nacional I+D+i.

  • Investigadores principales: Ángel Orte Gutiérrez y Luis Crovetto González

  • Financiación: 116,160€

  • Duración: Enero 2018 - Diciembre 2020

  • Página Web

• PARTNER GROUP - INSTITUTE MAX PLANCK OF BIOPHYSICS

  • Investigador principal: Ángel Pérez Lara

  • Financiación: 100,000€

  • Duración: Septiembre 2020 - Septiembre 2025

• SYNTHESIS AND APPLICATIONS OF HOMOCHIRAL PHOTOACTIVE ORGANIC AND METALLORGANIC SYSTEMS

  • CTQ2017-85454-C2-1-P . Plan Nacional I+D+i.

  • Investigadores principales: Delia Miguel Álvarez y Juan M. Cuerva Carvajal

  • Financiación: 105,000€

  • Duración: Enero 2018 - Diciembre 2020

• PROOF-OF-CONCEPT OF miRNAs AS EFFICIENT TUMORAL BIOMARKERS

  • AT17-5105_OTRI . Junta de Andalucía. Acciones de Transferencia.

  • Investigador principal: Ángel Orte Gutiérrez

  • Financiación: 45,818.39€

  • Duración: Octubre 2019 - Octubre 2020

  • Página Web

• NANOSCOPIO DE SÚPER-RESOLUCIÓN CON CAPACIDADES MULTIDIMENSIONALES PARA LA UNIDAD DE EXCELENCIA DE QUÍMICA APLICADA A BIOMEDICINA Y MEDIOAMBIENTE (UEQ)

  • EQC2018-004333-P . Plan Nacional I+D+i de ayudas a infraestructura.

  • Investigador responsable: Ángel Orte Gutiérrez

  • Financiación: 630,350€

  • Duración: Octubre 2018 - Diciembre 2020

• UNA PLATAFORMA MULTI-IMAGEN PARA LA EVALUACIÓN DEL METABOLISMO CELULAR. APLICACIÓN AL DIAGNÓSTICO DEL CÁNCER Y LA CITOTOXICIDAD DE OLIGÓMEROS AMILOIDES

  • CTQ2014-56370-R. Plan Nacional I+D+i.

  • Investigadores Principales: Ángel Orte Gutiérrez y Mª José Ruedas Rama

  • Financiación: 119,790€

  • Duración: Enero 2015 - Diciembre 2018

• MATERIALES ORGÁNICOS FUNCIONALES

  • CTQ2014-53598-R. Plan Nacional I+D+i.

  • Investigador principal: Juan M. Cuerva Carvajal

  • Financiación: 170,610€

  • Duración: Enero 2015 - Diciembre 2017

  • Página Web

• DIAGNÓSTICO DEL CÁNCER MEDIANTE UNA PLATAFORMA DE NANOSENSORES METABÓLICOS

  • XVII Concurso Nacional de Ayudas a la Investigación de la Fundación Ramón Areces. 2015-2017.

  • Investigador Principal: Ángel Orte Gutiérrez.

  • Financiación: 83,430€

  • Duración: Abril 2015 - Abril 2018

• microRNA BIOMARKERS IN AN INNOVATIVE BIOPHOTONIC SENSOR KIT FOR HIGH-SPECIFIC DIAGNOSIS (miRNA-DisEASY)

  • Horizon 2020 MSCA-RISE 690866

  • Coordinadora: Cristina Ress (Optoelettronica Italia).

  • Investigador responsable en la : Ángel Orte Gutiérrez.

  • Financiación total: 455,500.00€

  • Financiación para : 27,000€

  • Duración: Diciembre 2015 - Diciembre 2019

Tesis Doctorales (desde 2015)

• DISEÑO Y SÍNTESIS DE LIGANDOS ORGÁNICOS PARA EL DESARROLLO DE NUEVOS COMPLEJOS DE PALADIO, PLATINO Y PLATA CON NUEVAS PROPIEDADES ÓPTICAS Y ELECTRÓNICAS

  • Doctorando: Pablo Reiné Díaz

  • Directores: Delia Miguel Álvarez / Juan M. Cuerva Carvajal

  • Fecha de Lectura: 27 de Noviembre de 2020

  • Menciones: Doctorado Internacional

• SÍNTESIS Y APLICACIONES IN VIVO E IN VITRO DE NUEVOS COLORANTES ORGÁNICOS

  • Doctoranda: Pilar Herrero Foncubierta

  • Directores: Ángel Orte Gutiérrez / Delia Miguel Álvarez / Javier Rodriguez Granger

  • Fecha de Lectura: 27 de Septiembre de 2019

  • Menciones: Doctorado Internacional. Premio del grupo especializado en Química Biológica de la RSEQ.

• METABOLIC NANOSENSORS FOR THE IDENTIFICATION OF TUMORAL METABO-PHENOTYPES

  • Doctoranda: Consuelo Ripoll Lorente

  • Directores: Ángel Orte Gutiérrez / María J. Ruedas Rama / Miguel Martín Hernández

  • Fecha de Lectura: 7 de Mayo de 2019

  • Menciones: Doctorado Internacional

• DETECCIÓN SELECTIVA DE ANALITOS DE INTERÉS BIOLÓGICO A TRAVÉS DE NUEVAS SONDAS FLUORESCENTES. DISEÑO, SÍNTESIS Y CARACTERIZACIÓN FOTOFÍSICA DE LAS MISMAS. APLICACIÓN EN MEDIOS BIOLÓGICOS

  • Doctoranda: Virginia Puente Muñoz

  • Directores: Luis Crovetto González / José M. Paredes Martínez

  • Fecha de Lectura: 17 de Julio de 2017

  • Menciones: Doctorado Internacional

• STRUCTURAL CHANGES IN PRE-AMYLOIDOGENIC AGGREGATES OF THE SH3 DOMAIN OF α-SPECTRIN

  • Doctorando: Fabio Castello

  • Directores: Ángel Orte Gutiérrez / María José Ruedas Rama / Salvador Casares Atienza

  • Fecha de Lectura: 8 de Julio de 2016

  • Menciones: Doctorado Internacional

Colaboradores Habituales

• Juan M. Cuerva. UGR - Dept. Química Orgánica
  • Colaborador desde 2011
• Araceli González Campaña. UGR - Dept. Química Orgánica
  • Colaborador desde 2011
• M. Dolores Girón. UGR - Dept. Bioquímica y Biología Molecular II
  • Colaborador desde 2012
• Rafael Salto. UGR - Dept. Bioquímica y Biología Molecular II
  • Colaborador desde 2012
• Luis Álvarez de Cienfuegos. UGR - Dept. Química Orgánica
  • Colaborador desde 2015
• Juan J. Díaz Mochón. UGR - Dept. Química Farmacéutica y Orgánica
  • Colaborador desde 2014
• Noël Boens. U. Leuven (Bélgica) - Dept. Química
  • Colaborador desde 2003
• Natividad Gálvez. UGR - Dept. Química Inorgánica
  • Colaborador desde 2015
• Michela Denti. U. Trento (Italia) - CIBIO
  • Colaborador desde 2015
• Unidad de Excelencia en Química aplicada a Biomedicina y Medioambiente
  • Colaborador desde 2017